Compound | IC50 | Ratio (Radiometric/LC-MS/MS) | ||||
---|---|---|---|---|---|---|
Radiometric | LC-MS/MS | |||||
μM | ||||||
Tranylcypromine | 10.1 ± 0.4 | 11.7 ± 2.6 | 0.86 | |||
Indomethacin | > 100 | > 100 | N.A. | |||
Progesterone | 0.62 ± 0.38 | 0.66 ± 0.44 | 0.94 | |||
Amitriptyline | 27.4 ± 3.6 | 35.8 ± 6.3 | 0.77 | |||
Ticlopidine | 0.50 ± 0.20 | 0.34 ± 0.07 | 1.46 | |||
Propranolol | >30 | >30 | N.A. | |||
Omeprazole | 6.1 ± 1.0 | 4.4 ± 1.6 | 1.38 | |||
Fluoxetine | 10.9 ± 2.8 | 4.7 ± 0.1 | 2.32 | |||
Cimetidine | >100 | >100 | N.A. | |||
Ketoconazole | 14.8 ± 3.4 | 9.7 ± 2.6 | 1.53 | |||
Imipramine | 11.5 ± 2.3 | 16.8 ± 3.6 | 0.68 | |||
Miconazole | 0.01 ± 0.0004 | 0.008 ± 0.001 | 1.25 | |||
Carbamazepine | 20.5 ± 5.8 | 42 ± 18 | 0.49 | |||
Ethynylestradiol | 3.5 ± 0.3 | 8.8 ± 2.1 | 0.40 | |||
Clotrimazole | 0.69 ± 0.12 |
| 1.3 ± 0.4 | 0.53 |
N.A., not applicable.