TABLE 1

Elevation of serum enzyme activities in rats treated with APAP

Rats were sacrificed 18 h after APAP treatment. Each value represents the mean ± S.E. for six rats.

APAP
AST
ALT
SDH
units/ml
0 mg/kg i.p. 75.9 ± 3.9 30.7 ± 2.2 8.0 ± 3.6
250 mg/kg i.p. 77.4 ± 3.7 34.2 ± 4.6 10.5 ± 4.5
500 mg/kg i.p. 72.6 ± 3.6 34.6 ± 3.6 13.4 ± 5.5
750 mg/kg i.p. 183 ± 57 123 ± 54 202 ± 130
1000 mg/kg i.p.
426 ± 152*
433 ± 173*
791 ± 309*

  • ↵* Significant differences from control were shown only in rats treated with a 1000-mg/kg dose of APAP (Student's t test, p < 0.05).