Statistics for the predicted rat pharmacokinetic parameters
For more details on methods Vd1, Vd2, CL1, and CL2, see Materials and Methods.
Parameter | Method | Source of Rat Ptp Data | afe | rmse | Percentage within 2-fold Error | Percentage within 3-fold Error |
|---|---|---|---|---|---|---|
| Vss (liters) | Vd1 | Predicteda | 1.07 | 3.23 | 42.3 | 53.8 |
| Vss (liters) | Vd2 | Predicted + Experimentalb | 1.51 | 2.52 | 73.1 | 88.5 |
| Vss (liters) | Vd2 | Predicteda | 1.10 | 3.10 | 65.4 | 80.8 |
| CL (l/h) | CL1 | 3.59 | 0.468 | 34.6 | 53.8 | |
| CL (l/h) | CL2 |
| 1.23 | 0.311 | 84.6 | 100 |
↵ a Only predicted rat Ptp values were used for all tissue compartments.
↵ b In instances where the experimental in vivo rat Ptp was not available, the value for that particular tissue compartment was predicted as described for method Vd2. All experimentally determined in vivo rat Ptp values are given in Table 2.