Water solubility and relative lipophilicity of GCs
The relative lipophilicity of GCs was estimated by the chromatographic capacity factor log k′0; k′ was determined as k′ = (tR - t0)/t0, where tR is the retention time for the analyte and t0 is the retention time for a non-retained analyte in a given liquid chromatography system.
BUD | BUD oleate | FP | MF | CIC | CIC-AMa | |
|---|---|---|---|---|---|---|
| Water solubility (μg/ml) | 14 | N.D.b | <0.1 | <0.1 | <0.1 | 7 |
| Relative lipophilicity (log k′0) | 2.6 | 6 | 3.1 | 2.9 | 3.2 | 3.0 |
| Normalized lipophilicity (k′0,BUD = 1) | 1 | 2500 | 3.2 | 2.0 | 4.0 | 2.5 |
↵ a log k′0 for CIC-AM oleate was not determined in this article; however, according to Nave et al. (2004), the lipophilicity of CIC-AM oleate is 5 times greater than that of BUD oleate as determined by log D value (octanol/phosphate buffer distribution).
↵ b N.D., not determined due to liquid chromatography-UV detection limit; expected water solubility ≪0.1 μg/ml.