Substrate | Rate Incubations in Hepatocytes | Rate Incubations in LPCs | Route Incubations in Hepatocytes and LPCs | Km of Reactiona | ||
---|---|---|---|---|---|---|
μM | μM | |||||
7-EC | 1 | 2 | 25 | 3.9 μM (1) | ||
ER | 1 | 2 | 20 | 0.18-0.21 μM (2) | ||
Coumarin | 1 | 2 | 25 | 0.3-2.3 μM (2) | ||
Bupropion | 1 | 2 | 50 | 67-168 μM (2) | ||
Diclofenac | 1 | 2 | 50 | 3.4-52 μM (2) | ||
S-Mephenytoin | 1 | 2 | 100 | 13-35 μM (2) | ||
Bufuralol | 1 | 2 | 20 | 9-15 μM (2) | ||
Astemizole | 1 | 2 | 50 | 1.8 μM (3) | ||
Midazolam | 1 | 2 | 25 | 1-14 μM (2) | ||
Testosterone | 1 | 2 | 100 | 52-94 μM (2) | ||
7-HC | 1 | 2 | 25 | UGT 79 μM (4) | ||
SULT ~3 μM (4) | ||||||
1-Naphthol | 1 | 2 | 25 | 40.2 μM (5) | ||
4-methyl umbelliferone | 1 | 2 | 25 | 920 μM (6) | ||
Acetaminophen | 1 | 2 | 25 | UGT 2.2 mM (7) | ||
SULT <1 mM (8) | ||||||
BDP | 1 | 2 | 50 | |||
Salbutamol | 1 | 2 | 25 | 142 μM (9) | ||
Budesonide | 1 | 2 | 25 | 126.9 μM (10) | ||
Formoterol | 1 | 2 | 25 | 827.6 μM (11) |
↵ a (1) Bayliss et al., 1994; (2) Huang and Stifano, 2006; (3) Matsumoto et al., 2002; (4) Wang et al., 2006; (5) Cho et al., 2006; (6) Green et al., 1998; (7) Mutlib et al., 2006; (8) Kane et al., 1995; (9) Pacifici et al., 1996; (10) Sudsakorn et al., 2005; (11) Zhang et al., 2000.