(S)-Tofisopam Metabolite | Plasma Data | ||||||
---|---|---|---|---|---|---|---|
2 h | 2 h* | 4 h | 4 h* | ||||
ng/ml | ng/ml | ||||||
Tofisopam | 188 ± 102 | 186 ± 103 | 69.2 ± 47.4 | 68.5 ± 46.2 | |||
M1 | 145 ± 34.4 | 726 ± 126 | 52.7 ± 11.5 | 433 ± 95 | |||
M2 | 0.40 ± 0.32 | 0.74 ± 0.46 | 0.17 ± 0.13 | 0.37 ± 0.31 | |||
M3 | 21.0 ± 7.8 | 88.2 ± 31.1 | 7.83 ± 3.70 | 45.9 ± 18.6 | |||
M4 | 0.20 ± 0.15 | 1.28 ± 0.44 | 0.05 ± 0.07 | 0.77 ± 0.35 | |||
M5 | 78.2 ± 17.1 | 210 ± 48.5 | 37.2 ± 10.7 | 136 ± 39 | |||
M6 | 3.33 ± 1.02 | 4.70 ± 1.05 | 1.14 ± 0.41 | 2.34 ± 0.60 |
↵* Samples were incubated with Glusulase for 1 h to remove glucuronide and sulfate conjugates.