TABLE 1

Dosing regimen, target receptors, and marker genes of xenobiotic activator compounds used for inducer studies

Compounds were dosed i.p. or by oral gavage (p.o.).

Compound
CAS Number
Dosing Regimen
Activated Receptor
Marker Gene
TCDD 1746-01-6 37 μg/kg, CO, i.p.
PCB-126 57465-28-8 300 μg/kg, CO, i.p. AhR Cyp1a1
BNF 6051-87-2 200 mg/kg CO, i.p.
PB 50-06-6 100 mg/kg, SAL, i.p.
TCPOBOP 76150-91-9 3 mg/kg, CO, i.p. CAR Cyp2b10
DAS 592-88-1 200 mg/kg, CO, i.p.
PCN 1434-54-4 200 mg/kg, CO, i.p.
SPR 52-01-7 200 mg/kg, CO, i.p. PXR Cyp3a11
DEX 50-02-2 75 mg/kg, CO, i.p.
CLOF 637-07-0 500 mg/kg CO, i.p.
CPFB 52214-84-3 40 mg/kg, CO, i.p. PPARα Cyp4a14
DEHP 117-81-7 1000 mg/kg, CO, i.p.
OPZ 64224-21-1 150 mg/kg, CO, p.o.
EXQ 91-53-2 250 mg/kg, CO, p.o. Nrf2 Nqo1
BHA
25013-16-5
350 mg/kg, CO, i.p.

  • CO, corn oil vehicle; SAL, saline vehicle.