Rates of 3 mM phenyl valerate hydrolysis in liver and skin microsomal and cytosolic fractions expressed as micromoles per minute per milligram of protein (micromoles per minute per gram of wet weight tissue in italics)
Data are mean ± S.E.M., n = 4 for rat and human, n = 3 for minipig.
Liver | Skin | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Minipig | Human | Rat | Minipig | Human | Rat | |||||
| Microsomes | 11.0 ± 0.5 | 5.22 ± 0.52 | 5.67 ± 0.27 | 0.023 ± 0.002 | 1.06 ± 0.13 | 0.403 ± 0.037 | ||||
| 129 ± 4 | 51.30 ± 5.61 | 56.2 ± 7.74 | 0.029 ± T0.001 | 2.84 ± 0.35 | 1.60 ± 0.13 | |||||
| Cytosol | 1.04 ± 0.05 | 0.200 ± 0.090 | 0.24 ± 0.02 | 0.041 ± 0.011 | 0.390 ± 0.120 | 0.224 ± 0.026 | ||||
|
|
108 ± 12
|
20.0 ± 9.0
|
29.8 ± 3.5
|
0.646 ± 0.165
|
12.4 ± 3.8
|
7.91 ± 0.84
| ||||