TABLE 1

Effects of KC500 on the activity of hepatic microsomal alkoxyresorufin O-dealkylases in Wistar and Gunn rats

Animals were killed at 4 days after the final administration of KC500 (10 mg/kg i.p., once daily for 10 days). The values shown are expressed as the mean ± S.E. for four to five animals.

Substrates
Wistar
Gunn
Control
KC500
Control
KC500
nmol/mg protein/min nmol/mg protein/min
7-Benzyloxyresorufin 0.07 ± 0.01 3.34 ± 0.33* 0.03 ± 0.003 1.08 ± 0.27*
7-Pentoxyresorufin 0.03 ± 0.003 0.43 ± 0.05* 0.02 ± 0.003 0.22 ± 0.05*
7-Ethoxyresorufin
0.14 ± 0.01
9.02 ± 0.09*
0.21 ± 0.01
2.21 ± 0.29*

  • ↵* P < 0.05, significantly different from each control.