TABLE 3

Biliary and perfusate excretion of APAP-glu relative to its total amount in the IPL system

Excretory rates and liver content of APAP-glu represent the amounts accumulated by the end of the experiment and refer to the total amount of this metabolite synthesized by IPL by that time. Results are expressed as mean ± S.D. (n = 3-6).

	Control	EE	SL	EE+SL
Perfusate (%)	64 ± 4	93 ± 1^a	56 ± 5^b	80 ± 8^a ^b ^c
Biliary (%)	36 ± 4	6 ± 1^a	43 ± 5^a ^b	20 ± 8^a ^b ^c
Hepatic content (%)	0.057 ± 0.013	0.033 ± 0.008^a	0.066 ± 0.015^b	0.028 ± 0.012^a ^b ^c
Biliary/perfusate ratio	0.57 ± 0.10	0.07 ± 0.02^a	0.78 ± 0.16^a ^b	0.27 ± 0.12^a ^b ^c

↵ a Significantly different from controls (p <0.05).
↵ b Significantly different from EE (p <0.05).
↵ c Significantly different from SL (p <0.05).