Parameter | Control | Coadministered | Treatment |
---|---|---|---|
Cmax (ng/ml) | 492.65 ± 33.21 | 458.21 ± 78.05 | 960.14 ± 93.39** |
tmax (min) | 120.0 ± 0.0 | 108.0 ± 6.6 | 120.0 ± 0.0 |
AUC0-8 (ng/ml × h) | 2140.04 ± 187.87 | 2347.63 ± 287.83 | 3440.26 ± 210.45* |
Total AUCa (ng/ml × h) | 3570.91 ± 106.26 | 4114.26 ± 103.22 | 4582.18 ± 382.65* |
CLoral (ml/h) | 2.36 ± 0.07 | 2.02 ± 0.06 | 1.85 ± 0.15** |