TABLE 2

Pharmacokinetic parameters of midazolam in rat plasma in control, coadministered, and treatment groups following a p.o. dose of 20 mg/kg

Data are presented as mean ± S.E.M. (n = 5).

Parameter
Control
Coadministered
Treatment
Cmax (ng/ml) 123.21 ± 14.82 239.71 ± 46.82 259.20 ± 38.71
tmax (min) 28.8 ± 5.9 28.8 ± 4.7 32.5 ± 5.8
AUC0-4 (ng/ml × h) 255.06 ± 27.40 470.01 ± 88.36 657.02 ± 135.59*
Total AUCa (ng/ml × h) 476.88 ± 109.50 776.18 ± 94.58 1835.40 ± 422.13*
CLoral (ml/h)
13.40 ± 3.21
7.59 ± 0.76
3.33 ± 0.66*

  • ↵* p ≤ 0.05 significant difference compared with control.

  • ↵ a Total AUC, area under concentration curve extrapolated to infinity.