TABLE 1

Amount of Gly-NC100194 and NC100194 excreted in urine samples from the highest-dose group, including accumulated recovery of the metabolites and radioactivity

Sample ID and Collection Period	Volume	Gly-NC100194	NC100194	Ratio of NC100194 to Gly-NC100194	Accumulated Recovery (% of Injected Dose)
Sample ID and Collection Period	Volume	Gly-NC100194	NC100194	Ratio of NC100194 to Gly-NC100194			Gly-NC100194 + NC100194	^99mTc
h	ml	ng/ml	ng/ml	%
#41
1	150	823	61	8	47.5	48.2
2	52	166	24	14	51.0	62.2
4	80	109	32	30	55.0	73.8
8	200	90	37	41	63.8	84.3
13	250	26	<LOQ	NA	66.1	91.4
#42
1	23	699	213	30	7.6	8.3
2	320	236	209	89	57.2	52.9
4	90	186	148	80	67.7	64.9
7	140	48	92	190	74.3	70.5
8	70	70	50	71	77.3	73.7
13	500	<LOQ	<LOQ	NA	77.3	76.6
#43
1	290	403	22	6	44.3	50.5
2	62	187	16	9	48.8	66.0
4	390	24	<LOQ	NA	52.2	82.7
8	68	5.9	10	166	52.6	83.4
13	260	<LOQ	<LOQ	NA	52.6	85.1
#44
1	88	1559	61	4	51.3	33.6
2	44	871	64	7	66.1	45.0
3	240	43	<LOQ	NA	69.8	55.2
4	80	140	17	12	74.3	59.5
7	260	49	16	33	80.2	67.7
8	80	60	25	41	82.6	70.1
9	26	130	108	83	84.7	70.8
13	88	56	<LOQ	NA	86.4	72.8
#45
1	45	277	438 ^a	158^a	10.6 ^a	7.4
2	85	132	449 ^a	340^a	26.6 ^a	22.0
4	38	73	436 ^a	598^a	32.7 ^a	27.7
8	450	40	190 ^a	475^a	65.7 ^a	50.2
13	290	29	72 ^a	252^a	75.3 ^a	55.4
#48
1	90	860	39	5	29.1	40.2
2	37	411	45	11	35.1	51.1
4	41	304	48	16	40.3	60.2
8	135	62	29	47	44.5	69.3
13	170	28	<LOQ	NA	46.2	72.0
#49
1	124	761	41	5	35.7	24.7
2	78	263	15	6	43.5	36.3
3	230	92	18	19	52.4	46.0
4	143	24	<LOQ	NA	53.6	50.5
5	345	26	<LOQ	NA	56.9	54.6
8	350	10	<LOQ	NA	58.1	58.8
10	150	<LOQ	<LOQ	NA	58.1	60.0
16	200	<LOQ	45	NA	60.9	61.6
#50
1	93	1394	84	6	49.3	16.2
2	140	104	29	28	55.9	26.6
4	350	48	52	107	67.5	39.8
7	300	23	11	47	71.0	45.7
8	230	24	<LOQ	NA	73.0	48.2
13	350	<LOQ	<LOQ	NA	73.0	50.6

NA, not applicable.
↵ a Overestimated because of the presence of endogenous substance.