Single-dose intravenous pharmacokinetic parameters of CP-671,305 in Sprague-Dawley rats
Data are presented as mean ± S.D. from three male rats and were derived from noncompartmental analysis.
Intravenous | AUC0-∞ | CLp | Vdss | T½ |
|---|---|---|---|---|
| μg · h/ml | ml/min/kg | l/kg | h | |
| CP-671,305 alone (normal rats) | 5.96 ± 1.40 | 8.70 ± 1.80 | 0.81 ± 0.30 | 6.50 ± 1.30 |
| + Cyclosporin A | 22.4 ± 2.90*** | 2.30 ± 0.25** | 0.20 ± 0.08 | 4.10 ± 1.00 |
| + Rifampicin | 26.0 + 9.73*** | 2.20 ± 0.90** | 0.40 ± 0.08 | 5.00 ± 1.90 |
| CP-671,305 alone (bile duct-exteriorized rats) | 4.15 ± 1.70 | 13.4 ± 4.70* | 0.44 ± 0.10 | 0.88 ± 0.10*** |
***P < 0.0001, **P < 0.001, and *P < 0.05.