Single-dose intravenous pharmacokinetics of CP-671,305 (1 mg/kg) in wild-type Wistar rats and Mrp2-deficient TR- rats
Data are presented as mean ± S.D. from three male rats and were derived from noncompartmental analysis.
Parameter | Wild-type | TR |
|---|---|---|
| CLp (ml/min/kg) | 5.6 ± 2.8 | 4.5 ± 1.3 |
| CLbile (ml/min/kg) | 1.5 ± 0.8 | 0.4 ± 0.1* |
| CLurine (ml/min/kg) | 1.3 ± 0.8 | 2.2 ± 0.6* |
| Vdss (l/kg) | 0.6 ± 0.2 | 0.4 ± 0.1 |
| AUC0-∞ (μg · h/ml) | 3.5 ± 1.5 | 4.0 ± 1.5 |
| T½ (h) | 3.1 ± 1.3 | 4.2 ± 0.6 |
***P < 0.0001, **P < 0.001, and *P < 0.05.