Predicted relative contributions of CYP2C8, 2C9, 2C19, 2D6, and 3A4 to the overall oxidative metabolism of [14C]muraglitazar in the human liver at muraglitazar concentrations of 1, 2.5, 3.8, and 25 μM
Enzyme | FCYPi (Total Relative Contribution)a | ||||||
|---|---|---|---|---|---|---|---|
| 1 μM | 2.5 μM | 3.8 μM | 25 μM | ||||
| % | |||||||
| CYP2C8 | 12.2 | 12.3 | 12.3 | 12.7 | |||
| CYP2C9 | 14.7 | 14.8 | 14.8 | 15.0 | |||
| CYP2C19 | 36.3 | 35.5 | 34.8 | 28.1 | |||
| CYP2D6 | 0.55 | 0.57 | 0.60 | 0.77 | |||
| CYP3A4 | 36.3 | 36.9 | 37.5 | 43.4 | |||
| Total | 100 | 100 | 100 | 100 | |||
↵ a Based on the formation of M10, M11, M14, and M15, without consideration of formation of M1, M9, M16, and other minor radioactive peaks.