TABLE 3

Kinetic parameters for the formation of metabolites from [14C]vicriviroc with pooled human liver microsomes

Data are means ± S.E.

Kinetic Parametersa
M2/M3
M15
M16
M41
Km (μM) 14.7 ± 1.0 19.3 ± 2.69 9.05 ± 3.77 8.92 ± 0.82
Vmax (pmol/nmol of P450/min) 31.6 ± 0.88 25.2 ± 1.52 7.28 ± 1.03 22.9 ± 0.79
Vmax/Km (μl/nmol of P450/min)b
2.15
1.30
0.80
2.56

  • ↵ a Kinetic parameters were determined by GraFit 5.00.1 program

  • ↵ b Intrinsic clearance.