P450 Enzyme-Specific Reactions | P450 Involveda | M2/M3 | M15 | M41 |
---|---|---|---|---|
Caffeine N3-demethylation | CYP1A2 | 0.31 | 0.43 | 0.36 |
Coumarin 7-hydroxylation | CYP2A6 | 0.32 | 0.29 | 0.18 |
S-Mephenytoin N-demethylation | CYP2B6b | 0.86 | 0.89 | 0.86 |
Tolbutamide methyl-hydroxylation | CYP2C9 | 0.09 | 0.07 | 0.18 |
S-Mephenytoin 4′-hydroxylation | CYP2C19 | 0.48 | 0.37 | 0.39 |
Dextromethorphan O-demethylation | CYP2D6 | 0.29 | 0.32 | 0.14 |
Chlorzoxazone 6-hydroxylation | CYP2E1 | 0.23 | 0.23 | 0.61 |
Dextromethorphan N-demethylation | CYP3A4 | 0.90 | 0.91 | 0.89 |
Testosterone 6β -hydroxylation | CYP3A4/5 | 0.91c | 0.93d | 0.97e |
Lauric acid 12-hydroxylation | CYP4A11 | 0.04 | 0.07 | 0.01 |