UGT isoforms used in the present study
Isoforms | Lot Number | Activity |
|---|---|---|
| pmol/min/mg | ||
| UGT1A1 | 10 | 1000 |
| UGT1A3 | 11 | 150 |
| UGT1A4 | 2 | 1450 |
| UGT1A6 | 1 | 6970 |
| UGT1A8 | 15467 | 510 |
| UGT1A9 | 1 | 8740 |
| UGT1A10 | 23954 | 110 |
| UGT2B4 | 16905 | 700 |
| UGT2B7 | 11 | 1300 |
| UGT2B15 | 15468 | 2100 |
| UGT2B17 | 15397 | 2200 |
UGT1A1 and UGT1A3 activity was measured as estradiol 3-glucuronidation. UGT1A4 activity was determined as trifluoperazine glucuronidation. UGT2B17 activity was measured as eugenol glucuronidation. Activity of other UGT isoforms was determined as 7-hydroxy-4-trifluoromethylcoumarin glucuronidation.