Noncompartmental pharmacokinetic parameter estimates for DA following i.v. (0.5 μg/kg) and s.c. (2 μg/kg) administration in sheep
Values represent the mean ± S.D. for n = 4 animals.
Parameter | i.v. Bolus | Interdigital | Abdomen | Shoulder |
|---|---|---|---|---|
| s.c. Control (noncannulated) | ||||
| Cmax (ng/ml) | 20.7 ± 5.8 | 7.1 ± 1.0 | 12.6 ± 3.0 | |
| Tmax (h) range | 6-8 | 18-72 | 6-12 | |
| t1/2 (h) | 26.3 ± 3.4 | 30.5 ± 2.0 | 36.1 ± 9.3 | 29.0 ± 2.0 |
| Vss (ml/kg) | 69.5 ± 11.9 | |||
| CL (ml/h/kg) | 2.24 ± 0.31 | |||
| Fabs (%) | 106 ± 18 | 85 ± 20 | 92 ± 13 | |
| s.c. Central lymph-cannulated | ||||
| Flymph (%) | 92 ± 15 | 28 ± 4a | C.N.C. | |
| Fblood (%) | 6.3 ± 4.2 | 8.2 ± 3.4a | C.N.C. | |
| Fabs (%) |
| 99 ± 13 | 37 ± 7a | C.N.C. |
C.N.C., could not calculate because the lymph from this region emptied into the thoracic duct at a point distal to the cannulation site.
↵ a Incomplete profile up to 48 h.