TABLE 3

Percentage ± S.D. (n = 3-5) of urinary metabolites produced by hydration or GSH conjugation biotransformation pathways

Sex, Species, Dose	Hydration Pathway	GSH Pathway
Male, rat, 2 mg/kg	63.8 ± 1.2^a	35.1 ± 1.6^b
Male, rat, 20 mg/kg	68.0 ± 2.2^a	31.2 ± 2.5^b
Male, rat, 200 mg/kg	75.6 ± 1.0^a	21.6 ± 1.4^b
Female, rat, 200 mg/kg	73.9 ± 0.9	22.3 ± 1.4
Male, mouse, 200 mg/kg	73.0 ± 1.8	22.9 ± 1.5
Female, mouse, 20 mg/kg	60.7 ± 1.4	38.0 ± 1.6
Female, mouse, 200 mg/kg	65.9 ± 1.7^c	31.4 ± 2.3^c

↵ a,b Significant dose-related differences, data with the same superscript are significantly different.
↵ c Significantly different from other 200-mg/kg dose groups