TABLE 4
Pharmacokinetic parameters for the humanized WT anti-TNFα and the P257I/N434H and D376V/N434H variants in male cynomolgus monkeys after i.v. administration of 0.5 mg/kg
Serum concentrations were determined using a validated antigen capture (with TNFα) ELISA. Data are the mean ± S.D. of the pharmacokinetic parameters determined from three monkeys per group.