Enzyme activities for hydrolysis of the PON1 substrates diazoxon (DZO, 500 μM), chlorpyrifos-oxon (CPO, 500 μM), paraoxon (POX, 1 mM), and phenylacetate (PA, 3 mM) by 27 human liver microsomal (HLM) preparations in relation to PON1–192 genotype
Activities are expressed as nmol/min/mg protein, except PA hydrolysis (μmol/min/mg protein).
HLM | DZO Hydrolysis | CPO Hydrolysis | POX Hydrolysis | PA Hydrolysis | PON1-192 Genotype |
|---|---|---|---|---|---|
| 1 | 176.1 | 70.8 | 0.626 | 7.45 | |
| 2 | 100.6 | 140.5 | 1.21 | 12.4 | |
| 3 | 57.4 | 221.7 | 3.74 | 10.2 | RR |
| 4 | 88.2 | 182.1 | 1.43 | 10.6 | |
| 5 | 42.7 | 92.5 | 0.665 | 8.44 | |
| 6 | 76.1 | 151.6 | 1.04 | 9.49 | |
| 7 | 59.5 | 123.0 | 2.53 | 8.47 | RR |
| 8 | 134.6 | 53.1 | 0.838 | 10.1 | |
| 9 | 101.7 | 47.3 | 0.799 | 6.32 | QR |
| 10 | — | 39.0 | 2.63 | 9.65 | QR |
| 11 | — | 41.4 | 0.680 | 8.70 | QR |
| 12 | 64.7 | 20.7 | 0.243 | 6.72 | |
| 13 | 49.5 | 40.5 | 2.20 | 10.1 | RR |
| 14 | — | 17.9 | 0.173 | 4.06 | |
| 15 | — | 37.4 | 1.30 | 7.92 | QR |
| 16 | — | 43.0 | 0.633 | 6.96 | |
| 17 | — | 34.4 | 0.450 | 8.03 | QR |
| 18 | 74.8 | 130.5 | 3.89 | 11.5 | RR |
| 19 | 66.6 | 160.4 | 4.00 | 12.5 | RR |
| 20 | 111.4 | 95.9 | 1.64 | 11.2 | |
| 21 | — | 222.7 | 3.87 | 17.6 | |
| 22 | 243.6 | 139.0 | 5.95 | 12.5 | RR |
| 23 | 47.4 | 70.3 | 1.09 | 8.43 | QR |
| 24 | 126.8 | 194.3 | 4.73 | 14.5 | QR |
| 25 | — | 228.1 | 4.42 | 15.7 | |
| 26 | 185.6 | 288.1 | 9.60 | 19.9 | QR |
| 27 | 62.8 | 240.1 | 2.06 | 12.1 | QQ |
—, not determined.