LSB | RA | LA | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AUC(0-tn) | Cmax | t1/2β | AUC(0-tn) | Cmax | t1/2β | AUC(0-tn) | Cmax | t1/2β | |||||||
mg · h/kg | μg/g | h | mg · h/kg | μg/g | h | mg · h/kg | μg/g | h | |||||||
Heart | 8.26 | 22.75 ± 15.58 | 1.02 | 0.34 | 1.08 ± 0.95 | 1.39 | 4.02 | 5.22 ± 2.32 | 1.84 | ||||||
Liver | 22.26 | 85.28 ± 38.15 | 0.79 | 0.04 | 0.29 ± 0.16 | 0.43 | 1.20 ± 0.47 | 1.61 | |||||||
Spleen | 3.24 | 11.29 ± 5.84 | 0.49 | 0.01 | 0.07 ± 0.06 | 0.29 | 0.46 ± 0.21 | 1.91 | |||||||
Lung | 27.14 | 102.60 ± 43.33 | 0.57 | 1.68 | 3.00 ± 0.82 | 0.19 | 2.81 | 4.87 ± 0.55 | 0.8 | ||||||
Kidney | 41 | 136.65 ± 64.94 | 0.7 | 10.84 | 43.65 ± 18.11 | 0.36 | 2.67 | 5.05 ± 0.92 | 0.78 | ||||||
Brain | 1.04 | 2.15 ± 0.67 | 0.76 | 0.01 | 0.06 ± 0.03 |
| 0.27 | 0.27 ± 0.10 | 1.15 |