TABLE 1

Pharmacokinetic parameters of d-NNA and l-NNA after i.v. bolus injection of d-NNA (32 mg/kg) or l-NNA (16 mg/kg) in conscious rats (n = 5 in each group) pretreated with the vehicle (0.9% NaCl saline, 4 ml/kg, i.v.) or sodium benzoate (400 mg/kg, i.v.)

All readings are mean ± S.E.M.

Parameters	d-NNA	d-NNA (Benzoate)	l-NNA	l-NNA (Benzoate)
AUC_{(0-7 h) (mg/l/h)}	31.32 ± 2.36	54.34 ± 8.05^a	52.58 ± 2.60	58.82 ± 17.00
CL_(l/h/kg)	0.98 ± 0.07	0.49 ± 0.12^a	0.19 ± 0.04^a	0.16 ± 0.03^b
t _{1/2 (h)}	0.58 ± 0.04	1.37 ± 0.32^a	5.21 ± 1.69^a	6.31 ± 1.97^b
AUC_{(0-7 h) (mg/l/h) (l-NNA after d-NNA)}	28.98 ± 3.72
T _max	2.20 ± 0.20
C _max	6.73 ± 0.96
t _{1/2 (h)}	8.60 ± 2.58

↵ a,b Significant (P < 0.05) differences from respective d-NNA group and d-NNA + benzoate group, respectively.