Peak plasma drug characteristics of 7 mg of prochlorperazine (nominal dose) delivered as a 5-s intravenous infusion and as a thermally generated aerosol in a single breath to dogs
Data are listed as mean ± S.D. (n = 4).
Route of Drug Administration | Predicted by Recirculatory Pharmacokinetic Model | Observed | ||||
|---|---|---|---|---|---|---|
| tmax | Cmax | tmax | Cmax | |||
| min | ng/ml | min | ng/ml | |||
| Intravenous over 5 s | 0.56 ± 0.18 | 3277 ± 612 | 0.50 ± 0.14 | 3482 ± 767 | ||
| Aerosol in a single breath | 0.38 ± 0.05 | 3156 ± 777 | 0.33 ± 0.07 | 3262 ± 975 | ||