Test Compound | Concentration | l-CEX Metabolisma | d-CEX Uptakeb | |
---|---|---|---|---|
pmol/min/mg protein | ||||
Control | 473 ± 14 | 95.4 ± 12.9 | ||
d-CEX | 10 mM | 172 ± 9** | N.T. | |
l-CEX | 10 mM | N.T. | 37.8 ± 7.7* | |
7-ADCA | 10 mM | N.T. | 92.1 ± 4.3 | |
l-Ala | 10 mM | 394 ± 7* | 86.4 ± 9.0 | |
d-Ala-d-Ala | 10 mM | 330 ± 7** | 76.0 ± 10.8 | |
l-Ala-l-Ala-l-Ala | 10 mM | 44.0 ± 0.6** | 36.5 ± 2.0** | |
Gly-Sar | 10 mM | 231 ± 2** | 45.3 ± 6.1** | |
Valacyclovir | 10 mM | 109 ± 6** | 33.8 ± 3.8** | |
Enalapril | 10 mM | 16.1 ± 5.0** | 36.3 ± 7.6* | |
Ubenimex | 10 mM | 0.572 ± 0.755** | 39.5 ± 6.0* | |
PMSF | 1 mM | 382 ± 12* | 94.9 ± 7.1 | |
Aprotinin | 2 μg/ml | 444 ± 11 | 81.6 ± 10.7 | |
Leupeptin | 100 μM | 417 ± 12* | 75.3 ± 5.4 | |
EDTA | 5 mM | 103 ± 2** | 67.6 ± 6.5 | |
Pepstatin-A | 1 μM | 381 ± 20* | 79.4 ± 9.9 | |
Mock |
| 145 ± 5** | 40.3 ± 4.3** |