Enzyme | Compound | IC50 | ||||
---|---|---|---|---|---|---|
Single P450 | P450 Cocktail | Literature | ||||
μM | ||||||
CYP2B6 | Ketoconazole | 4 | 4 | 3.5a | ||
Tranylcypromine | 10 | 6 | 3.2a | |||
Ticlopidine | 0.06 | 0.05 | 0.1a | |||
CYP2C8 | Ketoconazole | 4 | 4 | 5.5b | ||
Tranylcypromine | 103 | 113 | 12b | |||
>100a | ||||||
Quercetin | 3.3 | 5.6 | 4b | |||
Paclitaxel | 24 | 23 | 13.3b | |||
Montelukast | 0.01 | 0.009 | 0.009b | |||
Ritonavir | 1 | 2 | 3b | |||
Tamoxifen | 10 | 3 | 3.3b | |||
Nifedipine | 23 | 20 | 9.7b | |||
CYP3A5 | Ketoconazole | 0.3 | 0.23 | 0.15c | ||
0.11c | ||||||
Erythromycin | 15 | 17 | 64c | |||
| Diltiazem | 37 | 48 | 117c |