Rates of formation of the monohydroxylated metabolites of MK-0524, M1 and M4, by recombinant human P450s
MK-0524 (10 μM) was incubated for 90 min with P450 microsomes (20 pmol P450) in the presence of NADPH at 37°C. Values represent mean; n = 2.
P450 | M1 | M4 |
|---|---|---|
| pmol/pmol · h | pmol/pmol · h | |
| CYP1A1 | 0.09 | 0.2 |
| CYP2A6 | N.D. | N.D. |
| CYP2C9 | 1.9 | 2.4 |
| CYP2C19 | N.D. | 0.17 |
| CYP2D6 | N.D. | N.D. |
| CYP2E1 | N.D. | N.D. |
| CYP3A4 | 19.2 | 27 |
N.D., not detected.