In vivo human clearance values for n = 28 compounds with the key parameters for prediction
References for plasma CL data are available at www.capkr.man.ac.uk
Compound | Observed Plasma Clearance | Number of in Vivo Studies | Number of Individuals | RB | fup |
|---|---|---|---|---|---|
| ml/min/kg | |||||
| Naproxen | 0.106 | 1 | 10 | 0.55 | 0.01 |
| Diazepam | 0.38 | 14 | 131 | 0.55 | 0.022 |
| Antipyrine | 0.65 | 15 | 216 | 1 | 0.97 |
| Ibuprofen | 0.84 | 1 | 12 | 0.55 | 0.01 |
| Theophylline | 0.87 | 43 | >339 | 0.83 | 0.44 |
| Alprazolam | 1.0 | 20 | 237 | 0.78 | 0.78 |
| Ketoprofen | 1.2 | 1 | 7 | 0.55 | 0.01 |
| Lorazepam | 1.2 | 10 | 121 | 1 | 0.09 |
| Caffeine | 1.3 | 1 | 8 | 1.075 | 0.7 |
| Oxazepam | 1.6 | 1 | 31 | 1.11 | 0.05 |
| Furosemide | 1.7 | 0.55 | 0.012 | ||
| Gemfibrozil | 1.7 | 0.55 | 0.03 | ||
| Prednisolone | 2.4 | 12 | 123 | 1 | 0.1 |
| Flunitrazepam | 3.4 | 8 | 127 | 0.78 | 0.22 |
| Triazolam | 4.6 | 10 | 127 | 0.76 | 0.1 |
| Midazolam | 6.0 | 17 | 151 | 0.55 | 0.042 |
| Methylprednisolone | 6.7 | 8 | 58 | 1 | 0.22 |
| Chlorpromazine | 8.6 | 1.17 | 0.05 | ||
| Codeine | 9.5 | 2 | 20 | 1 | 0.93 |
| Timolol | 11 | 2 | 18 | 0.84 | 0.4 |
| Diltiazem | 12 | 1 | 0.22 | ||
| Desipramine | 12 | 3 | >13 | 0.96 | 0.18 |
| Lidocaine | 13 | 8 | 66 | 0.89 | 0.3 |
| Propranolol | 13 | 1 | 6 | 0.83 | 0.13 |
| Imipramine | 14 | 3 | >24 | 1.066 | 0.1 |
| Metoprolol | 17 | 3 | 31 | 1.13 | 0.89 |
| Naloxone | 22 | 1.22 | 0.56 | ||
| Propofol | 36 | 3 | 41 | 1.25 | 0.02 |