Pharmacokinetic parameters of tolbutamide after an oral administration in rats
Tolbutamide was administered orally at a dose of 20 mg/kg to rats 1 h after the injection of pomegranate juice or 5% glucose in phosphoric acid (pH 3) (3 ml p.o., each). Pharmacokinetic parameters were expressed as the geometric mean and 90% confidence intervals (body weight was expressed as the arithmetic mean ± S.D.).
Control | Pomegranate Juice | |
|---|---|---|
| Number of animals | 6 | 5 |
| Body weight (g) | 300 ± 18 | 292 ± 8 |
| Cmax (μg/ml) | 91.1 (74.6-111.2) | 106.6 (87.8-116.8) |
| Tmax (h) | 0.89 (0.46-1.74) | 0.87 (0.37-1.30) |
| AUC (μg/ml · h) | 641.7 (600.3-685.9) | 781.7 (708.6-818.6)* |
| MRT (h) | 7.01 (6.10-8.06) | 7.39 (6.80-7.69) |
| t1/2 (h) | 4.93 (4.26-5.71) | 5.17 (4.79-5.36) |
↵* p < 0.05 versus control values.