Pharmacokinetic parameters of KTZ following oral (5, 20 mg/kg) administration of KTZ concomitant with MDZ (0.3 or 1 mg/kg) or FEX (1 or 5 mg/kg)
Each value represents the mean ± S.D. of four monkeys.
KTZ Dose | Coadministration | Tmax | Cmax | t½ | AUCinf |
|---|---|---|---|---|---|
| h | ng/ml | h | h · ng/ml | ||
| 5 mg/kg | MDZ (oral dosing; 1 mg/kg) | 2.5 ± 1.0 | 41 ± 23 | 3.0 ± 1.0 | 148 ± 88 |
| 20 mg/kg | 5.0 ± 2.6 | 346 ± 226 | 2.5 ± 0.2 | 2477 ± 1185 | |
| 5 mg/kg | MDZ (intravenous dosing; 0.3 mg/kg) | 3.0 ± 1.2 | 53 ± 39 | 2.9 ± 1.1 | 190 ± 90 |
| 20 mg/kg | 3.5 ± 1.0 | 574 ± 470 | 2.9 ± 0.5 | 2067 ± 973 | |
| 5 mg/kg | FEX (oral dosing; 5 mg/kg) | 2.8 ± 1.5 | 51 ± 32 | 2.9 ± 1.6 | 160 ± 60 |
| 20 mg/kg | 3.5 ± 1.9 | 550 ± 394 | 3.2 ± 0.8 | 1882 ± 937 | |
| 20 mg/kg | FEX (intravenous dosing; 1 mg/kg) | 4.0 ± 1.6 | 255 ± 96 | 2.6 ± 0.4 | 1639 ± 411 |