Pharmacokinetic parameters of FEX following intravenous (1 mg/kg) or oral (5 mg/kg) administration of FEX with a concomitant oral dose of vehicle or KTZ (5, 20 mg/kg)
Each value represents the mean ± S.D. of four monkeys.
Intravenous (1 mg/kg FEX) | Oral (5 mg/kg FEX) | |||||||
|---|---|---|---|---|---|---|---|---|
| +Vehicle | +KTZ (20 mg/kg) | +Vehicle | +KTZ (5 mg/kg) | +KTZ (20 mg/kg) | ||||
| Cmax (ng/ml) | 269 ± 8 | 516 ± 218 | 350 ± 115 | |||||
| Tmax (h) | 1.8 ± 0.5 | 2.3 ± 1.3 | 4.0 ± 2.8 | |||||
| t½ (h) | 3.7 ± 0.2 | 4.1 ± 0.3 | 6.6 ± 1.0 | 5.1 ± 1.6 | 4.8 ± 2.4 | |||
| CLtot (ml/h/kg) | 385 ± 64 | 372 ± 75 | ||||||
| Vdss (ml/kg) | 302 ± 59 | 389 ± 102 | ||||||
| AUCinf (h · ng/ml) | 2469 ± 407 | 2592 ± 576 | 793 ± 97 | 1735 ± 337* | 2077 ± 902 | |||
| F (%) | 6.6 ± 1.8 | 14.6 ± 5.1* | 17.5 ± 9.9 | |||||
| Ratios (KTZ/Vehicle) | ||||||||
| Cmax | 1.9 ± 0.8 | 1.3 ± 0.4 | ||||||
| AUCinf | 2.2 ± 0.4 | 2.6 ± 1.1 | ||||||
| F |
|
|
| 2.2 ± 0.4 | 2.6 ± 1.1 | |||
↵* p < 0.025, compared with the values in the monkeys coadministered with vehicle.