Estimated elimination half-life (in days) of ISIS 301012 from selected tissues in rat and monkey
Tissue | Rata | Monkey |
|---|---|---|
| Dose | 5 mg/kg [3H]ISIS 301012 | 4 mg/kg ISIS 301012 |
| Kidneyb | >28 | 7c, 33 |
| Liver | 13 | 34 |
| Mesenteric lymph node | >28 | 35 |
| Heart | >28 | 18 |
NM, not measured.
↵ a Value is reported as >28 days because the sampling times were collected for 28 days (less than one half-life) and were insufficient to determine elimination half-life. In addition, half-life was estimated from total radioactivity.
↵ b Whole kidney in rat; kidney cortex in monkey.
↵ c Concentration-time profile seems biphasic with a 7-day initial half-life and apparent terminal elimination half-life of 33 days.