The pharmacokinetics parameters (n = 6) of glabridin after p.o. administration at 5 and 20 mg/kg, and i.v. bolus injection at 5 mg/kg
Data are the mean ± S.D.
Parameter | p.o. (5 mg/kg) | p.o. (20 mg/kg) | i.v. (5 mg/kg) |
|---|---|---|---|
| Tmax (h) | 4.33 ± 1.86 | 4.50 ± 2.17 | N.C. |
| Cmax (ng/ml) | 15.10 ± 4.72 | 60.41 ± 18.87 | 422.96 ± 123.92 |
| t1/2β (h) | 2.38 ± 0.70 | 2.41 ± 0.74 | 1.92 ± 0.60 |
| AUC0-24h (ng/ml · h) | 96.49 ± 32.34 | 387.98 ± 137.28 | 1301.48 ± 375.79 |
| AUC0-∞ (ng/ml · h) | 103.54 ± 34.03 | 413.30 ± 127.72 | 1388.49 ± 400.22 |
| CL (ml/min/kg) | N.C. | N.C. | 59.01 |
| Vd (l/kg) | N.C. | N.C. | 2.72 |
|
| 7.45% | 7.44% | N.C. |
N.C., not calculated.