TABLE 2

Permeability values of glabridin across isolated perfused rat ileum with mesenteric vein cannulation

Data are the mean ± S.D.

Concentration of Glabridin in Perfusion Solution
Plumen × 10-4
Pblood × 10-5
Ratio of Plumen/Pblood
cm/s
0.1 μM 6.51 ± 0.72 8.63 ± 0.97a 7.54
    + Verapamil (100 μM) 6.64 ± 0.63 21.32 ± 3.12a,b 3.11
    + Probenecid (200 μM) 6.57 ± 0.59 9.23 ± 1.14a,c 7.12
    + MK-571 (100 μM) 6.72 ± 0.43 9.55 ± 1.03a 7.12
    + Celecoxib (100 μM) 6.48 ± 0.59 8.65 ± 1.12a 7.49
0.5 μM 8.22 ± 0.91c 10.23 ± 1.17a,c 8.04
    + Verapamil (100 μM) 8.42 ± 0.63 28.31 ± 3.05a,b 2.97
    + Probenecid (200 μM) 8.28 ± 0.51 11.13 ± 1.27a 7.44
    + MK-571 (100 μM) 8.40 ± 1.01 10.83 ± 1.37a 7.76
    + Celecoxib (100 μM) 8.24 ± 0.61 11.01 ± 1.06a 7.48
2.0 μM 11.54 ± 1.31c 14.42 ± 1.55a,c 8.00
    + Verapamil (100 μM) 12.24 ± 1.41 36.79 ± 4.07a,b 3.33
    + Probenecid (200 μM) 11.89 ± 1.41 13.93 ± 1.63a 8.54
    + MK-571 (100 μM) 12.22 ± 1.42 16.67 ± 1.82a 7.33
    + Celecoxib (100 μM)
12.04 ± 1.61
15.48 ± 1.95a
7.78

  • ↵ a P < 0.05, Pblood vs Plumen.

  • ↵ b P < 0.05, Pblood in the presence of a transporter inhibitor vs Pblood in the absence of a transporter inhibitor.

  • ↵ c P < 0.05, Pblood at 0.5 or 2.0 μM vs Pblood at 0.1 μM.