TABLE 3

The pharmacokinetic parameters (n = 6) of glabridin at 5 mg/kg by gavage with or without combined oral verapamil at 25 or 100 mg/kg

Data are the mean ± S.D.

Parameter	Glabridin Alone (5 mg/kg)	Glabridin + Verapamil
Parameter	Glabridin Alone (5 mg/kg)			25 mg/kg	100 mg/kg
AUC_0-24h (ng/ml · h)	97.41 ± 34.58	116.21 ± 36.36^a	170.52 ± 52.28^a,^b
AUC_0-∞ (ng/ml · h)	104.81 ± 35.16	125.22 ± 37.29^a	183.11 ± 53.62^a,^b
C_max (ng/ml)	15.02 ± 4.59	19.01 ± 5.38^a	25.38 ± 7.62^a,^b
T_max (h)	4.15 ± 0.97	2.25 ± 0.52^a	2.15 ± 0.46^a
t_1/2β (h)	3.20 ± 0.93	3.52 ± 0.96^a	3.76 ± 0.92^a
F	7.55	9.02	13.19

↵ a P < 0.05, control (glabridin alone) vs combination treatment (glabridin + verapamil).
↵ b P < 0.05, glabridin + verapamil (25 mg/kg) vs glabridin + verapamil (100 mg/kg).