TABLE 2

Pharmacokinetic parameters of total radioactivity in plasma samples after single oral administration of 14C-RWJ-333369 in mice, rats, rabbits, and dogs

Parameter
Mice (50 mg/kg)a
Rats (30 mg/kg)a
Female Rabbitsb
Male Dogsc (20 mg/kg)
Male
Female
Male
Female
(100 mg/kg)
(200 mg/kg)
Cmax (μg-Eq/ml) 25.3 20.2 15.6 15.6 83.4 97.8 24.6 (1.75)
Tmax (h) 1.0 1.0 3.0 3.0 1.5 2.0 1.8 (0.50)
t (h) 3.7 4.1 6.6 5.6 14.6 15.8 44.9 (38.0)
AUC0-t (μg-Eq · h/ml) 95.8 93.6 174.8 177.5 654.7 1119.9 215.0 (246.2)
AUC0-inf (μg-Eq · h/ml)
97.3
95.6
192.0
188.0
663.2
1133.6
222.1 (285.4)

  • ↵ a Data were derived from pooled plasma in mice and in rats.

  • ↵ b Data from female rabbits were either the mean of two animals (100 mg/kg dose) or data from one animal (200 mg/kg dose).

  • ↵ c Data are the mean (±S.D.) from four animals.