TABLE 2

Relative mRNA expression levels of SLCs in intestinal sections (n = 10)

SLCs are shown in descending order according to their relative mRNA expression levels in different intestinal sections. SLCs with relative mean mRNA expression levels >0.01, and thus considered detectable, are highlighted in bold. The corresponding median values obtained from the 10 patients are given in parentheses for the detectable SLC mRNAs.

Duodenum
Ileum
Colon Ascendens
Colon Transversum
Colon Descendens
SLC
Mean ± S.D. (Median)
SLC
Mean ± S.D. (Median)
SLC
Mean ± S.D. (Median)
SLC
Mean ± S.D. (Median)
SLC
Mean ± S.D. (Median)
PEPT1 3.87 ± 2.52 (3.52) PEPT1 3.79 ± 2.19 (3.02) OCTN1 0.43 ± 0.40 (0.24) OCTN1 0.70 ± 0.61 (0.59) OCTN1 0.86 ± 0.94 (0.67)
OCTN1 0.53 ± 0.54 (0.37) OCTN1 1.27 ± 1.33 (0.83) OCTN2 0.34 ± 0.20 (0.30) OCTN2 0.24 ± 0.08 (0.26) PEPT1 0.25 ± 0.16 (0.20)
CNT2 0.32 ± 0.26 (0.27) ASBT 0.42 ± 0.25 (0.39) PEPT1 0.14 ± 0.12 (0.11) PEPT1 0.15 ± 0.10 (0.14) OCTN2 0.24 ± 0.09 (0.24)
OCTN2 0.09 ± 0.07 (0.09) CNT2 0.15 ± 0.11 (0.14) OATP2B1 0.02 ± 0.02 (0.02) OATP2B1 0.03 ± 0.04 (0.02) ENT2 0.05 ± 0.09 (0.02)
ASBT 0.09 ± 0.05 (0.08) OCTN2 0.10 ± 0.05 (0.10) ENT2 0.02 ± 0.01 (0.02) ENT2 0.02 ± 0.01 (0.01) OATP2B1 0.03 ± 0.03 (0.02)
CNT1 0.06 ± 0.06 (0.05) SERT 0.09 ± 0.06 (0.08) SERT 0.007 ± 0.003 ASBT 0.006 ± 0.006 ASBT 0.005 ± 0.004
SERT 0.04 ± 0.02 (0.02) CNT1 0.06 ± 0.04 (0.05) ASBT 0.007 ± 0.008 SERT 0.004 ± 0.003 OATP4A1 0.004 ± 0.002
OATP2B1 0.02 ± 0.02 (0.02) OATP2B1 0.06 ± 0.10 (0.01) OATP4A1 0.006 ± 0.004 OATP4A1 0.004 ± 0.003 CNT2 0.004 ± 0.004
ENT2 0.009 ± 0.006 ENT2 0.006 ± 0.005 CNT2 0.003 ± 0.003 CNT2 0.003 ± 0.003 SERT 0.003 ± 0.003
OAT2 0.006 ± 0.006 CNT3 0.005 ± 0.006 CNT3 0.002 ± 0.003 OCT1 0.002 ± 0.002 CNT3 0.003 ± 0.004
CNT3 0.003 ± 0.004 OATP1A2 0.003 ± 0.004 OCT1 0.002 ± 0.001 ENT1 0.001 ± 0.001 OCT1 0.001 ± 0.001
OATP4A1 0.002 ± 0.001 OATP4A1 0.002 ± 0.001 ENT1 0.001 ± 0.0008 CNT3 0.001 ± 0.001 ENT1 0.001 ± 0.001
ENT1 0.001 ± 0.0008 OAT2 0.001 ± 0.001 OAT2 0.0006 ± 0.001 OATP1A2 0.0005 ± 0.0006 OATP1A2 0.0009 ± 0.001
OCT1 0.0004 ± 0.0004 ENT1 0.001 ± 0.0009 OATP1A2 0.0004 ± 0.0004 OAT2 0.0005 ± 0.0006 OAT2 0.0007 ± 0.001
OATP1A2
0.0002 ± 0.0001
OCT1
0.0004 ± 0.0004
CNT1
0.0002 ± 0.0001
CNT1
0.0001 ± 0.0003
CNT1
0.00004 ± 0.00004