Michaelis-Menten kinetic parameters of metabolite formation from diltiazem and MA in HLMs
Results are parameter estimates (standard error) obtained by SAAM II software assuming one enzyme reaction.
Km | Vmax | Intrinsic Clearancea | Percentage Inhibition by 1 μM Ketoconazole | |
|---|---|---|---|---|
| μM | pmol/mg/min | μl/mg/min | ||
| Diltiazem to MA | 54 (5) | 1881 (115) | 35 | 94b |
| MA to MD | 19 (8) | 385 (1) | 20 | 93c |