TABLE 7

Free fraction (fc) of diltiazem and its sequential metabolites in hepatocyte incubations over time

Free fraction was calculated as the ratio of supernatant concentration to total concentration, mean (SD), n = 3 individual incubations.



Time (min)

0
15
40
60
Diltiazem 0.89 (0.12) 1.04 (0.06) 0.94 (0.11) 0.92 (0.14)
MA 0.51 (0.01) 0.55 (0.07) 0.66 (0.01)
MD

0.61 (0.10)
0.55 (0.01)
0.63 (0.06)