Drug | fu,plasma | fu,brain | Kp,brain-/- | Kp,brain+/+ | Reference for Kp,brain |
---|---|---|---|---|---|
Alfentanil (Al) | 0.26 ± 0.04 | 0.32 ± 0.11 | 0.53 | 0.19 | |
Amprenavir (A) | 0.075 ± 0.008 | 0.091 ± 0.005 | 1.0 | 0.072 | Polli et al., 1999 |
Cetirizine (C) | 0.160 ± 0.009 | 0.072 ± 0.007 | 0.080 | 0.020 | Chen et al., 2003 |
Cimetidine (Ci) | 0.81 ± 0.07 | 0.53 ± 0.10 | 0.031 | 0.033 | |
Desloratadine (Dl) | 0.055 ± 0.002 | 0.0071 ± 0.0008 | 14 | <1.0 | Chen et al., 2003 |
Dexamethasone (Dex) | 0.272 ± 0.014 | 0.098 ± 0.010a | 0.70 | 0.30 | Schinkel et al., 1995b |
Digoxin (Dg) | 0.33 ± 0.02 | 0.0156 ± 0.0011 | 1.5 | 0.08 | Schinkel et al., 1995b |
Diphenhydramine (D) | 0.33 ± 0.02 | 0.058 ± 0.003 | 0.70 | 9.0 | Chen et al., 2003 |
Doxorubicin (Dox) | 0.22 ± 0.03 | 0.0014 ± 0.0005 | 0.0025 | 0.00077 | Kusuhara and Sugiyama, 2001 |
Eletriptan (Ele) | 0.28 ± 0.03 | 0.055 ± 0.004 | 14 | 0.30 | Evans et al., 2003 |
Fentanyl (F) | 0.17 ± 0.04 | 0.07 ± 0.005 | 4.5 | 2.4 | |
Fexofenadine (Fex) | 0.35 ± 0.03 | 0.077 ± 0.014 | 0.30 | 0.17 | Cvetkovic et al., 1999 |
Hydroxyzine (H) | 0.062 ± 0.008 | 0.014 ± 0.002 | 4.8 | 3.8 | Chen et al., 2003 |
Indinavir (I) | 0.058 ± 0.007 | 0.100 ± 0.008 | 0.81 | 0.084 | Kim et al., 1998 |
Ivermectin (Iv) | 0.024 ± 0.008a | 0.00009 ± 0.00007b | 2.5 | 0.094 | Schinkel et al., 1995a |
Loperamide (Lop) | 0.023 ± 0.005c | 0.0046 ± 0.0005d | 5.7 | 0.096 | |
Loratadine (L) | 0.0045 ± 0.00017 | 0.00178 ± 0.00015 | 3.3 | 1.6 | Chen et al., 2003 |
Meperidine (Me) | 0.38 ± 0.03 | 0.13 ± 0.019 | 7.0 | 6.8 | |
Methadone (M) | 0.147 ± 0.007 | 0.029 ± 0.002 | 20 | 4.0 | |
Morphine (Mor) | 0.50 ± 0.04 | 0.41 ± 0.11 | 0.72 | 0.49 | Schinkel et al., 1995b |
Naratriptan (N) | 0.58 ± 0.03 | 0.23 ± 0.02 | 1.1 | 0.42 | Evans et al., 2003 |
Nelfinavir (Nel) | 0.0010 ± 0.0004 | 0.00053 ± 0.00004 | 2.6 | 0.086 | Kim et al., 1998 |
Peclitaxel (Pax) | 0.021 ± 0.002 | 0.0028 ± 0.0004 | 4.0 | 0.50 | Kemper et al., 2004 |
Quinidine (Q) | 0.16 ± 0.03 | 0.037 ± 0.003 | 4.8 | 0.20 | Kusuhara et al., 1997 |
Ranitidine (Ra) | 0.96 ± 0.05 | 0.96 ± 0.13 | 0.039 | 0.022 | |
Ritonavir (Rit) | 0.0027 ± 0.0005 | 0.0106 ± 0.0016 | 2.3 | 0.17 | Yamazaki et al., 2001 |
Rizatriptan (Riz) | 0.62 ± 0.02 | 0.348 ± 0.014 | 0.85 | 0.20 | Evans et al., 2003 |
Saquinavir (Sq) | 0.00043 ± 0.00007 | 0.00190 ± 0.00016 | 0.88 | 0.13 | Kim et al., 1998 |
Sufentanil (Su) | 0.054 ± 0.014 | 0.034 ± 0.010 | 4.8 | 1.6 | |
Sumatriptan (Sum) | 0.63 ± 0.03 | 0.36 ± 0.03 | 0.22 | 0.13 | Evans et al., 2003 |
Triprolidine (T) | 0.31 ± 0.02 | 0.092 ± 0.002 | 3.6 | 5.9 | Chen et al., 2003 |
Verapamil (V) | 0.11 ± 0.03 | 0.033 ± 0.02 | 3.3 | 0.43 | Hendrikse et al., 1998 |
Vinblastine (Vi) | ≥ 0.09 | 0.0046 ± 0.0004 | 19 | 1.7 | Schinkel et al., 1994 |
Zolmitriptan (Z) | 0.98 ± 0.11a | 0.54 ± 0.08 | 0.085 | 0.038 |
Evans et al., 2003
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