Summary of the quantitative data, expressed as nmol/g liver, in rat liver homogenates after administration (i.p.) of 100 mg/kg tolmetin to clofibric acid-pretreated rats (n = 3) or control rats (n = 3)
Values are expressed as the mean ± S.D. (n = 3).
Covalent Binding | Tol | Tol-CoA | Tol-O-G | Tol-Tau | Tol-Car | |
|---|---|---|---|---|---|---|
| Clofibric acid-treateda | 4.2 ± 1.1 | 530 ± 220 | 4.4 ± 1.9 | 19 ± 5.5 | 4.0 ± 2.0 | 0.64 ± 0.21 |
| Control | 0.9 ± 0.3 | 550 ± 130 | 0.6 ± 0.2 | 25 ± 5.3 | 7.2 ± 6.0 | 0.08 ± 0.07 |
↵ a Pretreatment was performed with clofibric acid for 7 days (150 mg/kg/day i.p.). Livers were removed 2 h after administration of tolmetin.