Microsomal Protein | Nominal Concentration of MA | Percentage Freea | Time-Averaged Factorb | Time-Averaged Free Concentration ([I]u,ave) of MAc |
---|---|---|---|---|
μM | μM | |||
0.2 mg/ml | 0.25 | 0.81 (0.10) | 0.94 | 0.19 |
0.5 | 0.77 (0.08) | 0.99 | 0.38 | |
1 | 0.77 (0.09) | 0.94 | 0.73 | |
2 | 0.80 (0.08) | 1.01 | 1.60 | |
4 | 0.79 (0.07) | 1.02 | 3.20 | |
0.4 mg/ml | 0.25 | 0.64 (0.04) | 0.96 | 0.15 |
0.5 | 0.65 (0.04) | 0.85 | 0.28 | |
1 | 0.68 (0.08) | 0.92 | 0.63 | |
2 | 0.68 (0.08) | 0.94 | 1.28 | |
4 | 0.65 (0.08) | 0.92 | 2.38 | |
0.8 mg/ml | 0.25 | 0.63 (0.01) | 0.80 | 0.13 |
0.5 | 0.63 (0.04) | 0.79 | 0.25 | |
1 | 0.63 (0.03) | 0.87 | 0.55 | |
2 | 0.64 (0.02) | 0.87 | 1.11 | |
| 4 | 0.59 (0.04) | 0.92 | 2.16 |