Transplacental pharmacokinetic parameters of salicylic acid and antipyrine
Each value represents the estimate ± S.D. (68.3% confidence interval).
|
|
K 1 |
f b | K′1 |
f p, m | K″1 |
k 2 | K′1/k2 | K″1/k2 | |||
| ml/min/g cotyledon | ml/min/g cotyledon | ml/min/g cotyledon | min-1 | ml/min/g cotyledon | |||||||
| Salicylic acid | 0.0407 ± 0.0062 | 0.902 | 0.0451 | 0.568a | 0.0256 | 0.0238 ± 0.0344 | 1.89 | 1.07 | |||
| Antipyrine | 0.0791 ± 0.0059 | 0.932 | 0.0849 | 0.884b | 0.0751 | 0.118 ± 0.093 | 0.726 | 0.642 | |||
|
|
k
3
|
K
4
| K′4 |
f
p, f
| K″4 |
V
p
| K″4/k3 |
k
s
| |||
| min-1 | ml/min/g cotyledon | ml/min/g cotyledon | ml/g cotyledon | ml/min/g cotyledon | min-1 | ||||||
| Salicylic acid | 0.176 ± 0.054 | 0.0813 ± 0.0284 | 0.0901 | 0.457a | 0.0412 | — | 0.512 | 0.234 | 1.81 × 10-4 | ||
| Antipyrine | — | — | — | 0.869b | — | 0.195 ± 0.050 | — | — | 0.108 ± 0.091 | ||
—, not applicable to antipyrine; K1, K′1, K″1, K4, K′4, K″4, clearance; k2, k3, ks, rate constants; fb, unbound fraction in perfusate; fb, unbound fraction in perfusate; fp,m, unbound fraction in human maternal plasma; fp,f, unbound fraction in human fetal plasma; Vp, distribution volume of placental compartment. See text for details.