Average percentages of serum metabolites of [14C]CP-122,721 in EM and PM human subjects after administration of a 30-mg (free base) oral dose
Percentage of Total Radioactivity in Human Serum (h Postdose) | |||
|---|---|---|---|
| Metabolite | EM Subjects (mean ± S.D., n = 4) | PM Subjects (mean, n = 2) | |
| M 3 | 25.2 ± 7 | 62.3 | |
| M 4 | 13.6 ± 3 | N.D. | |
| M5 | 5.2 ± 1 | 2.1 | |
| M15 (TFMSA) | 55.9 ± 5 | 29.4 | |
| CP-122,721 | N.D. | 5.6 | |
|
Total
|
99.9
|
99.4
| |
N.D., not detected.