TABLE 2

Effect of DPC 333 on the renal elimination of MTX in beagle dogs

Data are expressed as mean ± S.D. of triplicate determinations.

Parameter
−DPC 333
+DPC 333
Dose (nmol/kg) 1115 ± 0 1192 ± 52
Urine recovery (%)
0-2 h 8.1 ± 2.1 48.7 ± 8.7*
0-8 h 48.1 ± 8.8 82.7 ± 11.8*
0-48 h 58.7 ± 1.8 92.2 ± 14.0*
CLrenal (ml/min/kg)
0-2 h 0.4 ± 0.1 2.9 ± 0.5*
0-8 h 1.6 ± 0.4 3.0 ± 0.5*
0-48 ha
1.8 ± 0.1
2.9 ± 0.4*

  • ↵* P < 0.05 compared with the control (in the absence of DPC 333).

  • ↵ a CLrenal (0-48 h) was determined using U0-48 h/AUC0-∞.