Metabolic rates during 27 h of incubation and percentages of retained metabolic rates compared with 0 to 3 h of incubation in colon slices
Results (mean ± S.E.M.) are extracted from data in Figs. 2 and 6 (n = 3-6 rats); 7HC data are extracted from not shown data.
Metabolite Formed | 0-3 h (100%) | 5-8 h | 8-11 h | 24-27 h | |
|---|---|---|---|---|---|
| pmol/min/mg protein (%) | |||||
| 7HC (CYP1A, 1B) | 22.1 ± 9.5 | 31.5 ± 16 (143) | 17.6 ± 5.9 (80) | 7.2 ± 4.6 (32) | |
| 6β-TOH (CYP3A) | 4.7 ± 1.7 | 3.0 ± 2 (64) | 4.1 ± 1.3 (87) | 9.2 ± 1.8 (196) | |
| Androstenedione (several CYPs, 17β-HSD) | 95 ± 26 | 62 ± 8 (65) | 77 ± 24 (81) | 85 ± 24 (90) | |
| 7HC-GLUC | 653 ± 57 | 509 ± 45(78)** | 635 ± 194 (97) | 579 ± 212 (89) | |
| 7HC-SULF | 64 ± 6.4 | 58 ± 6 (91)* | 58 ± 16 (90) | 50 ± 7.5 (78) | |