Mean (S.D.) pharmacokinetic parameters of TG100435 and TG100855 following 5 mg/kg i.v. and i.p. dosing in mice and rats
Species | Route | Compound | C0 | AUC(0-∞) | t½ | Vd | CL | AUC0-∞a |
|---|---|---|---|---|---|---|---|---|
| ng/ml | ng · h/ml | h | l/kg | ml/min/kg | ng · h/ml | |||
| Mouse | i.v. | TG100435 | 873 | 4140 | 5.4 | 9.4 | 20.1 | |
| i.v. | TG100855 | 9030 | 5350 | 0.9 | 1.2 | 15.6 | 1390 | |
| i.p. | TG100855 | 4100 | 6520 | 2.8 | 2.6 | 11.6 | 1400 | |
| Rat | i.v. | TG100435 | 1650 (840) | 7030 (2170) | 8.9 (1.9) | 9.4 (1.7) | 12.7 (3.5) | |
| i.v. | TG100855 | 12,200 (3980) | 6050 (386) | 1.6 (0.2) | 1.9 (0.4) | 13.8 (0.9) | 539 (171) | |
|
| i.p. | TG100855 | 1080 (806) | 4990 (577) | 2.3 (1.4) | 3.3 (2.3) | 17.0 (2.0) | 498 (62) |
↵ a AUC of TG100435 converted from TG100855 after dosing with TG100855.