Mean (S.D.) pharmacokinetic parameters of TG100435 and TG100855 following 25 mg/kg p.o. administration in mice and rats
Species | Compound | Cmax | tmax | AUC0-∞ | AUC0-last | F | |
|---|---|---|---|---|---|---|---|
| ng/ml | h | ng · h/ml | % | ||||
| Mouse | TG100435 | 618 | 8 | 15,300 | 15,000 | 74 | |
| TG100855 | 171 | 1 | 939 | 912 | 3.5 | ||
| TG100435a | 113 | 7 | 1760 | 1740 | 6.8b | ||
| Rat | TG100435 | 348 (82) | 8 | 8010 (3850) | /980 (3810) | 23 | |
| TG100855 | 160 (85) | 3.5 (1.9) | 470 (145) | 467 (150) | 1.6 | ||
|
| TG100435a | 73.0 (31.8) | 4.0 (2.0) | 906 (437) | 881 (431) | 3.1b | |